BDBM50020897 CHEMBL3287255::US9216962, CFH367-C

SMILES ONC(=O)CCCCNC(=O)c1nc(sc1C1CC1)-c1nccs1

InChI Key InChIKey=MVJAEZIEZVJAFM-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50020897   

TargetHistone deacetylase 1(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020897(CHEMBL3287255 | US9216962, CFH367-C)
Affinity DataIC50: 65nMAssay Description:Enzyme activity of HDAC1,3 is determined using the substrate Ac-Lys-Tyr-Lys(Ac)-AMC while the enzyme activity of HDAC6 is assayed using the substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020897(CHEMBL3287255 | US9216962, CFH367-C)
Affinity DataIC50: 262nMAssay Description:Enzyme activity of HDAC1,3 is determined using the substrate Ac-Lys-Tyr-Lys(Ac)-AMC while the enzyme activity of HDAC6 is assayed using the substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020897(CHEMBL3287255 | US9216962, CFH367-C)
Affinity DataIC50: 785nMAssay Description:Enzyme activity of HDAC1,3 is determined using the substrate Ac-Lys-Tyr-Lys(Ac)-AMC while the enzyme activity of HDAC6 is assayed using the substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020897(CHEMBL3287255 | US9216962, CFH367-C)
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020897(CHEMBL3287255 | US9216962, CFH367-C)
Affinity DataIC50: 260nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020897(CHEMBL3287255 | US9216962, CFH367-C)
Affinity DataIC50: 790nMAssay Description:Inhibition of recombinant human HDAC6 using Boc-Lys(epsilon-acetyl)-AMC as substrate after 3 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020897(CHEMBL3287255 | US9216962, CFH367-C)
Affinity DataIC50: 95nMAssay Description:Inhibition of full length His6-tagged GST-fused recombinant human HDAC1 expressed in High5 insect cells using Ac-Lys-Tyr-Lys (e-acetyl)-AMC as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020897(CHEMBL3287255 | US9216962, CFH367-C)
Affinity DataIC50: 108nMAssay Description:Inhibition of full length His6-tagged GST-fused recombinant human HDAC3 expressed in High5 insect cells using Ac-Lys-Tyr-Lys (e-acetyl)-AMC as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50020897(CHEMBL3287255 | US9216962, CFH367-C)
Affinity DataIC50: 158nMAssay Description:Inhibition of full length His6-tagged GST-fused recombinant human HDAC4 expressed in High5 insect cells using Ac-Lys-Tyr-Lys (e-acetyl)-AMC as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020897(CHEMBL3287255 | US9216962, CFH367-C)
Affinity DataIC50: 68nMAssay Description:Inhibition of full length His6-tagged GST-fused recombinant human HDAC6 expressed in High5 insect cells using Boc-Lys (e-acetyl)-AMC as substrate aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020897(CHEMBL3287255 | US9216962, CFH367-C)
Affinity DataIC50: 61nMAssay Description:Inhibition of recombinant His6/GST-tagged human HDAC6 expressed in baculovirus infected High5 insect cells using Boc-Lys(epsion-acetyl)-AMC as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020897(CHEMBL3287255 | US9216962, CFH367-C)
Affinity DataIC50: 81nMAssay Description:Inhibition of recombinant His6/GST-tagged human HDAC1 expressed in baculovirus infected High5 insect cells using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020897(CHEMBL3287255 | US9216962, CFH367-C)
Affinity DataIC50: 74nMAssay Description:Inhibition of recombinant His6/GST-tagged human HDAC3 expressed in baculovirus infected High5 insect cells using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed