BDBM50020903 CHEMBL3287261::US9216962, CFH448-P

SMILES ONC(=O)CCCCNC(=O)c1nc(sc1-c1ccc(cc1)[N+]([O-])=O)-c1nccs1

InChI Key InChIKey=XJIIOWPKUDHNQA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50020903   

TargetHistone deacetylase 1(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020903(CHEMBL3287261 | US9216962, CFH448-P)
Affinity DataIC50: 105nMAssay Description:Enzyme activity of HDAC1,3 is determined using the substrate Ac-Lys-Tyr-Lys(Ac)-AMC while the enzyme activity of HDAC6 is assayed using the substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020903(CHEMBL3287261 | US9216962, CFH448-P)
Affinity DataIC50: 201nMAssay Description:Enzyme activity of HDAC1,3 is determined using the substrate Ac-Lys-Tyr-Lys(Ac)-AMC while the enzyme activity of HDAC6 is assayed using the substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020903(CHEMBL3287261 | US9216962, CFH448-P)
Affinity DataIC50: 1.07E+3nMAssay Description:Enzyme activity of HDAC1,3 is determined using the substrate Ac-Lys-Tyr-Lys(Ac)-AMC while the enzyme activity of HDAC6 is assayed using the substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020903(CHEMBL3287261 | US9216962, CFH448-P)
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020903(CHEMBL3287261 | US9216962, CFH448-P)
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020903(CHEMBL3287261 | US9216962, CFH448-P)
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of recombinant human HDAC6 using Boc-Lys(epsilon-acetyl)-AMC as substrate after 3 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed