BDBM50021218 (S)-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine::2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine(Nomifensine)::CHEMBL51697

SMILES CN1Cc2c(cccc2N)[C@@H](C1)c3ccccc3

InChI Key InChIKey=XXPANQJNYNUNES-UHFFFAOYSA-N

Data  3 KI  3 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50021218   

LigandPNGBDBM50021218(CHEMBL51697 | 2-Methyl-4-phenyl-1,2,3,4-tetrahydro...)
Affinity DataIC50: 830nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50021218(CHEMBL51697 | 2-Methyl-4-phenyl-1,2,3,4-tetrahydro...)
Affinity DataIC50: 48nMAssay Description:Inhibition of dopamine uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021218(CHEMBL51697 | 2-Methyl-4-phenyl-1,2,3,4-tetrahydro...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent noradrenaline transporter(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50021218(CHEMBL51697 | 2-Methyl-4-phenyl-1,2,3,4-tetrahydro...)
Affinity DataKi:  4nMAssay Description:Inhibition of human recombinant NET expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent dopamine transporter(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50021218(CHEMBL51697 | 2-Methyl-4-phenyl-1,2,3,4-tetrahydro...)
Affinity DataKi:  7nMAssay Description:Inhibition of human recombinant DAT expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50021218(CHEMBL51697 | 2-Methyl-4-phenyl-1,2,3,4-tetrahydro...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of human recombinant SERT expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed