BDBM50021912 6-(3-Trifluoromethyl-phenyl)-1,2,3,5,6,10b-hexahydro-pyrrolo[2,1-a]isoquinoline;HCl::CHEMBL286849

SMILES FC(F)(F)c1cccc(c1)[C@@H]1CN2CCC[C@@H]2c2ccccc12

InChI Key InChIKey=LWXKKDYZAXBAPH-UHFFFAOYSA-N

Data  13 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50021912   

TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021912(CHEMBL286849 | 6-(3-Trifluoromethyl-phenyl)-1,2,3,...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of uptake of tritiated norepinephrine (NE) in rat synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021912(CHEMBL286849 | 6-(3-Trifluoromethyl-phenyl)-1,2,3,...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of uptake of tritiated norepinephrine (NE) in rat synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50021912(CHEMBL286849 | 6-(3-Trifluoromethyl-phenyl)-1,2,3,...)
Affinity DataKi:  9.10nMAssay Description:Inhibition the uptake of tritiated serotonin (5-HT) by the serotonin transporter SERT in rat synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50021912(CHEMBL286849 | 6-(3-Trifluoromethyl-phenyl)-1,2,3,...)
Affinity DataKi:  9.10nMAssay Description:Inhibition the uptake of tritiated serotonin (5-HT) by the serotonin transporter SERT in rat synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50021912(CHEMBL286849 | 6-(3-Trifluoromethyl-phenyl)-1,2,3,...)
Affinity DataKi:  25.7nMAssay Description:Inhibition of the uptake of tritiated dopamine (DA) in rat synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50021912(CHEMBL286849 | 6-(3-Trifluoromethyl-phenyl)-1,2,3,...)
Affinity DataKi:  26nMAssay Description:Inhibition of the uptake of tritiated dopamine (DA) in rat synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50021912(CHEMBL286849 | 6-(3-Trifluoromethyl-phenyl)-1,2,3,...)
Affinity DataKi:  30nMAssay Description:Binding affinity towards alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50021912(CHEMBL286849 | 6-(3-Trifluoromethyl-phenyl)-1,2,3,...)
Affinity DataKi:  30nMAssay Description:Binding affinity towards alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021912(CHEMBL286849 | 6-(3-Trifluoromethyl-phenyl)-1,2,3,...)
Affinity DataKi:  602nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021912(CHEMBL286849 | 6-(3-Trifluoromethyl-phenyl)-1,2,3,...)
Affinity DataKi:  2.22E+3nMAssay Description:Binding affinity towards Dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021912(CHEMBL286849 | 6-(3-Trifluoromethyl-phenyl)-1,2,3,...)
Affinity DataKi:  2.57E+3nMAssay Description:Inhibition of uptake of tritiated norepinephrine (NE) in rat synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50021912(CHEMBL286849 | 6-(3-Trifluoromethyl-phenyl)-1,2,3,...)
Affinity DataKi:  2.92E+3nMAssay Description:Inhibition the uptake of tritiated serotonin (5-HT) by the serotonin transporter SERT in rat synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50021912(CHEMBL286849 | 6-(3-Trifluoromethyl-phenyl)-1,2,3,...)
Affinity DataKi:  7.69E+3nMAssay Description:Inhibition of the uptake of tritiated dopamine (DA) in rat synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed