BDBM50022036 CHEMBL298615::{1-[1-(1-Cyclohexylmethyl-2-hydroxy-3-{3-methyl-1-[(pyridin-4-ylmethyl)-carbamoyl]-butylcarbamoyl}-propylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

SMILES CC(C)C[C@H](NC(=O)CC(O)C(CC1CCCCC1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)NCc1ccncc1

InChI Key InChIKey=GIFCSVDZKULWCQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50022036   

TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022036({1-[1-(1-Cyclohexylmethyl-2-hydroxy-3-{3-methyl-1-...)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of porcine kidney reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022036({1-[1-(1-Cyclohexylmethyl-2-hydroxy-3-{3-methyl-1-...)
Affinity DataIC50: 0.990nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022036({1-[1-(1-Cyclohexylmethyl-2-hydroxy-3-{3-methyl-1-...)
Affinity DataIC50: 1.20nMAssay Description:Concentration required for 50% inhibition of human plasma reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed