BDBM50026883 CHEMBL437050

SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(O)=O

InChI Key InChIKey=GZWUQPQBOGLSIM-UHFFFAOYSA-N

Data  7 IC50  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50026883   

TargetMelanocortin receptor 3(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50026883(CHEMBL437050)
Affinity DataEC50:  5.90nMAssay Description:Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50026883(CHEMBL437050)
Affinity DataIC50: 71nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2019
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50026883(CHEMBL437050)
Affinity DataIC50: 72nMAssay Description:Binding affinity for Human Melanocortin 3 receptor expressed in L-cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50026883(CHEMBL437050)
Affinity DataEC50:  260nMAssay Description:Effective concentration required for intracellular cAMP accumulation by Melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50026883(CHEMBL437050)
Affinity DataEC50:  300nMAssay Description:Agonist activity at human MC1R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation measured after 3 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2019
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50026883(CHEMBL437050)
Affinity DataEC50:  490nMAssay Description:Effective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50026883(CHEMBL437050)
Affinity DataEC50:  550nMAssay Description:Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2019
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50026883(CHEMBL437050)
Affinity DataEC50:  700nMAssay Description:Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2019
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50026883(CHEMBL437050)
Affinity DataEC50:  710nMAssay Description:Agonist activity at human MC4R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2019
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50026883(CHEMBL437050)
Affinity DataIC50: 760nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK293 cells after 40 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2019
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50026883(CHEMBL437050)
Affinity DataIC50: 770nMAssay Description:Binding affinity for Human Melanocortin 4 receptor expressed in L-cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50026883(CHEMBL437050)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2019
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50026883(CHEMBL437050)
Affinity DataIC50: 2.20E+3nMAssay Description:Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2019
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50026883(CHEMBL437050)
Affinity DataIC50: 2.50E+3nMAssay Description:Binding affinity for Human Melanocortin 5 receptor expressed in L-cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed