BDBM50029686 CHEMBL3353405::US10227342, Example 25

SMILES COc1cc(N2CC(C2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(n1)-c1cnn2ccccc12

InChI Key InChIKey=RFZOHHKCEHQQBE-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50029686   

TargetInsulin-like growth factor 1 receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50029686(CHEMBL3353405 | US10227342, Example 25)
Affinity DataIC50: 26nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50029686(CHEMBL3353405 | US10227342, Example 25)
Affinity DataIC50: 35nMAssay Description:Inhibition of INSR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor [T790M](Human)
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM50029686(CHEMBL3353405 | US10227342, Example 25)
Affinity DataIC50: 100nMAssay Description:A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM50029686(CHEMBL3353405 | US10227342, Example 25)
Affinity DataIC50: 300nMAssay Description:A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM50029686(CHEMBL3353405 | US10227342, Example 25)
Affinity DataIC50: 750nMAssay Description:A compound's ability in selectively inhibiting Her2 exon 20 YVMA insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50029686(CHEMBL3353405 | US10227342, Example 25)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of EGFR L858R/T970M double mutant phosphorylation in human NCI-H1975 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
LigandPNGBDBM50029686(CHEMBL3353405 | US10227342, Example 25)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50029686(CHEMBL3353405 | US10227342, Example 25)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM50029686(CHEMBL3353405 | US10227342, Example 25)
Affinity DataIC50: 9.38E+5nMAssay Description:Inhibition of wild type EGFR phosphorylation in human LoVo cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed