BDBM50029688 CHEMBL3353409

SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ncc(C)c(n1)-c1cn(C)c2ccccc12

InChI Key InChIKey=FCHHBDZWKNCHCB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50029688   

TargetEpidermal growth factor receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50029688(CHEMBL3353409)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of EGFR L858R/T970M double mutant phosphorylation in human NCI-H1975 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50029688(CHEMBL3353409)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
LigandPNGBDBM50029688(CHEMBL3353409)
Affinity DataIC50: 1.56E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50029688(CHEMBL3353409)
Affinity DataIC50: 7.10E+4nMAssay Description:Inhibition of wild type EGFR phosphorylation in human LoVo cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50029688(CHEMBL3353409)
Affinity DataIC50: 1.96E+5nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed