BDBM50030245 CHEMBL3354073

SMILES OCCCCCC1CCN(CCCN2C(=O)CCc3ccccc23)CC1

InChI Key InChIKey=QKTOQRPNKITPLN-UHFFFAOYSA-N

Data  8 KI  8 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50030245   

TargetD(4) dopamine receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50030245(CHEMBL3354073)
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D4 receptor expressed in HEK293 cell membranes after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50030245(CHEMBL3354073)
Affinity DataIC50: 29nMAssay Description:Antagonist activity at human M1 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced response by BRET based beta-arrestin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50030245(CHEMBL3354073)
Affinity DataEC50:  112nMAssay Description:Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein engagement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50030245(CHEMBL3354073)
Affinity DataIC50: 126nMAssay Description:Antagonist activity at human SP/Myc epitope-tagged dopamine D4 receptor expressed in HEK293T cells assessed as inhibition of dopamine-induced RLuc8-f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50030245(CHEMBL3354073)
Affinity DataIC50: 151nMAssay Description:Antagonist activity at human SP/Myc epitope-tagged dopamine D4 receptor expressed in HEK293T cells assessed as inhibition of dopamine-induced mVenus-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50030245(CHEMBL3354073)
Affinity DataEC50:  204nMAssay Description:Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50030245(CHEMBL3354073)
Affinity DataKi:  447nMAssay Description:Displacement of [3H]NMS from human M4 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50030245(CHEMBL3354073)
Affinity DataKi:  468nMAssay Description:Displacement of [3H]NMS from human M1 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50030245(CHEMBL3354073)
Affinity DataKi:  603nMAssay Description:Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50030245(CHEMBL3354073)
Affinity DataKi:  676nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cell membranes after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50030245(CHEMBL3354073)
Affinity DataKi:  1.18E+3nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D2 receptor expressed in HEK293 cell membranes after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50030245(CHEMBL3354073)
Affinity DataIC50: 1.62E+3nMAssay Description:Antagonist activity at human M4 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced response by beta-arrestin engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50030245(CHEMBL3354073)
Affinity DataKi:  1.91E+3nMAssay Description:Displacement of [3H]NMS from human M3 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50030245(CHEMBL3354073)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at human M4 receptor expressed in HEK293T cells by BRET based Gq protein activation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50030245(CHEMBL3354073)
Affinity DataIC50: 3.31E+3nMAssay Description:Antagonist activity at human M4 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced response by BRET based Gq protein act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50030245(CHEMBL3354073)
Affinity DataKi:  4.57E+3nMAssay Description:Displacement of [3H]NMS from human M5 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50030245(CHEMBL3354073)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human M1 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced response by BRET based Gq protein act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50030245(CHEMBL3354073)
Affinity DataIC50: 1.23E+4nMAssay Description:Antagonist activity at human M4 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced response by BRET based Gq protein eng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50030245(CHEMBL3354073)
Affinity DataIC50: 2.63E+4nMAssay Description:Antagonist activity at human M1 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced response by BRET based Gq protein eng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed