BDBM50034417 4-Amino-N-[1,3,4]thiadiazol-2-yl-benzenesulfonamide::4-amino-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide::CHEMBL286737::US9320734, 100

SMILES Nc1ccc(cc1)S(=O)(=O)Nc1nncs1

InChI Key InChIKey=ATEAASNFYTUARU-UHFFFAOYSA-N

Data  2 KI  5 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50034417   

TargetRAC-alpha serine/threonine-protein kinase [1-123](Human)
The University of Texas System

US Patent
LigandPNGBDBM50034417(4-amino-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamid...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of AKT was measured by Western blotting using specific antibodies against phospho-Ser473-AKT in MiaPaCa-2 cells.Inhibition of AKT was meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
Go to US Patent

TargetRAC-alpha serine/threonine-protein kinase [1-123](Human)
The University of Texas System

US Patent
LigandPNGBDBM50034417(4-amino-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamid...)
Affinity DataKd:  1.51E+4nMAssay Description:SPR interaction analyses were performed with a Biacore 2000, using Biacore 2000 Control Software v3.2 and BIAevaluation v4.1 analysis software (Biaco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
Go to US Patent

TargetRAC-alpha serine/threonine-protein kinase [1-123](Human)
The University of Texas System

US Patent
LigandPNGBDBM50034417(4-amino-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamid...)
Affinity DataKd:  450nMAssay Description:SPR interaction analyses were performed with a Biacore 2000, using Biacore 2000 Control Software v3.2 and BIAevaluation v4.1 analysis software (Biaco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
Go to US Patent

TargetRAC-alpha serine/threonine-protein kinase [1-123](Human)
The University of Texas System

US Patent
LigandPNGBDBM50034417(4-amino-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamid...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of AKT was measured by Western blots using specific antibodies against phospho-Ser473-AKT in HT-29 lung cancer cells. Inhibition of the ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
Go to US Patent

TargetRAC-alpha serine/threonine-protein kinase [1-123](Human)
The University of Texas System

US Patent
LigandPNGBDBM50034417(4-amino-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamid...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of AKT was measured by Western blots using specific antibodies against phospho-Ser473-AKT in HT-29 lung cancer cells. Inhibition of the ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
Go to US Patent

TargetEndothelin-1 receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034417(4-amino-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamid...)
Affinity DataIC50: 5.70E+4nMAssay Description:Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50034417(4-amino-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamid...)
Affinity DataKd:  450nMAssay Description:Inhibition of pleckstrin homology domain of AKT by surface plasmon resonance spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50034417(4-amino-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamid...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of Akt phosphorylation in human BxPC3 cells by Western blottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase [1-123](Human)
The University of Texas System

US Patent
LigandPNGBDBM50034417(4-amino-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamid...)
Affinity DataKi: >5.00E+4nMAssay Description:SPR interaction analyses were performed with a Biacore 2000, using Biacore 2000 Control Software v3.2 and BIAevaluation v4.1 analysis software (Biaco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
Go to US Patent

TargetRAC-alpha serine/threonine-protein kinase(Mouse)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50034417(4-amino-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamid...)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of biotinylated phosphatidylinositol-3,4,5-phosphate from mouse AKT1 PH domain by surface plasmon resonance competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed