BDBM50037136 (4aS,7aR,12bS)-3-Cyclopropylmethyl-9-hydroxy-2,3,4,4a,5,6-hexahydro-1H-8-oxa-3-aza-benzo[d]fluoren-7-one::CHEMBL106910

SMILES Oc1cccc2c1O[C@H]1C(=O)CC[C@@H]3CN(CC4CC4)CC[C@]213

InChI Key InChIKey=XPJMFYKZWMSEIT-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50037136   

TargetMu-type opioid receptor(Guinea pig)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50037136((4aS,7aR,12bS)-3-Cyclopropylmethyl-9-hydroxy-2,3,4...)
Affinity DataKi:  19nMAssay Description:In vivo binding affinity against mu opioid receptor was measured by using labeled ligand [3H]naloxone (0.5 nM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50037136((4aS,7aR,12bS)-3-Cyclopropylmethyl-9-hydroxy-2,3,4...)
Affinity DataKi:  62nMAssay Description:In vivo binding affinity against kappa opioid receptor was measured by using labeled ligand [3H]ethylketocyclazocine (1 nM) with 500 nM DADLE and 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50037136((4aS,7aR,12bS)-3-Cyclopropylmethyl-9-hydroxy-2,3,4...)
Affinity DataKi:  134nMAssay Description:In vivo binding affinity against delta Opioid receptor was measured by using labeled ligand [3H]DADLE (1 nM) with 4 nM sufentanilMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50037136((4aS,7aR,12bS)-3-Cyclopropylmethyl-9-hydroxy-2,3,4...)
Affinity DataKi:  310nMAssay Description:In vivo binding affinity against sigma Opioid receptor was measured by using labeled ligand [3H]-SKF- 10,047 (1 nM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed