BDBM50044922 CHEMBL3311488

SMILES [O-][S@+](C1CCN(CC1)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(N[C@H](CCN2CCOCC2)CSc2ccccc2)c(c1)S(=O)(=O)C(F)(F)F)c1ccccc1-c1ccc(Cl)cc1

InChI Key InChIKey=HLFFHNOYYAYEOQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50044922   

TargetApoptosis regulator Bcl-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50044922(CHEMBL3311488)
Affinity DataIC50: 434nMAssay Description:Inhibition of human BCL-2 overexpressed in mouse FDC-P1 cells assessed as cell viability after 24 hrs by Cell Titer Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50044922(CHEMBL3311488)
Affinity DataIC50: 1.72E+3nMAssay Description:Inhibition of human BCL-xL overexpressed in mouse FDC-P1 cells assessed as cell viability after 24 hrs by Cell Titer Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50044922(CHEMBL3311488)
Affinity DataIC50: 19nMAssay Description:Inhibition of c-terminal 6xHis-tagged Bcl-2 (amino acids 1 to 204) (unknown origin) preincubated for 1 hr prior to substrate addition measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50044922(CHEMBL3311488)
Affinity DataIC50: 11nMAssay Description:Inhibition of c-terminal 6xHis-tagged Bcl-xL (amino acids 1 to 209) (unknown origin) preincubated for 1 hr prior to substrate addition measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed