BDBM50045244 (S)-3-[(S)-2-((R)-2-Acetylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-N-{(S)-1-[(S)-(S)-1-((S)-1-carboxy-2-(S)-1H-indol-3-yl-ethylcarbamoyl)-2-methyl-butylcarbamoyl]-2-methyl-butyl}-succinamic acid::Ac-D-Phe-D-Phe-Asp-Ile-Ile-Trp::CHEMBL313984

SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O

InChI Key InChIKey=GNRBLKLDFZWDTC-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50045244   

TargetEndothelin-1 receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50045244(Ac-D-Phe-D-Phe-Asp-Ile-Ile-Trp | (S)-3-[(S)-2-((R)...)
Affinity DataIC50: 200nMAssay Description:Effective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50045244(Ac-D-Phe-D-Phe-Asp-Ile-Ile-Trp | (S)-3-[(S)-2-((R)...)
Affinity DataIC50: 200nMAssay Description:Displacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetEndothelin receptor type B(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50045244(Ac-D-Phe-D-Phe-Asp-Ile-Ile-Trp | (S)-3-[(S)-2-((R)...)
Affinity DataIC50: 50nMAssay Description:Displacement of [125I]ET1 from Endothelin B receptor of rat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetEndothelin receptor type B(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50045244(Ac-D-Phe-D-Phe-Asp-Ile-Ile-Trp | (S)-3-[(S)-2-((R)...)
Affinity DataIC50: 60nMAssay Description:Effective concentration against Endothelin B receptor from rat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
TargetEndothelin receptor type B/1 receptor(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50045244(Ac-D-Phe-D-Phe-Asp-Ile-Ile-Trp | (S)-3-[(S)-2-((R)...)
Affinity DataIC50: 330nMAssay Description:Binding affinity against Endothelin receptor from rat heart ventricleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
TargetEndothelin receptor type B(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50045244(Ac-D-Phe-D-Phe-Asp-Ile-Ile-Trp | (S)-3-[(S)-2-((R)...)
Affinity DataIC50: 60nMAssay Description:Effective concentration against Endothelin B receptor from rat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50045244(Ac-D-Phe-D-Phe-Asp-Ile-Ile-Trp | (S)-3-[(S)-2-((R)...)
Affinity DataIC50: 200nMAssay Description:Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed