BDBM50045362 (20RS)-7-ethyl-8,11-dioxo-7,8,11,13-tetrahydro-10H-[1,3]dioxolo[5,4-g]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-7-yl 2-aminoacetate; hydrochloride::CHEMBL545250

SMILES CCC1(OC(=O)CN)C(=O)OCc2c1cc1-c3nc4cc5OCOc5cc4cc3Cn1c2=O

InChI Key InChIKey=ZCVLTIWFTLQSTM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50045362   

TargetDNA topoisomerase 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045362((20RS)-7-ethyl-8,11-dioxo-7,8,11,13-tetrahydro-10H...)
Affinity DataIC50: 430nMAssay Description:Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045362((20RS)-7-ethyl-8,11-dioxo-7,8,11,13-tetrahydro-10H...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of Topoisomerase I by cleavage complex formation in intact human HL-60 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed