BDBM50045664 3-[1-(4-Chloro-benzyl)-6-(isoquinolin-3-ylmethoxy)-4-methyl-4,5-dihydro-1H-3-thia-1-aza-acenaphthylen-2-yl]-2,2-dimethyl-propionic acid::CHEMBL430487

SMILES CC1Cc2c(OCc3cc4ccccc4cn3)ccc3n(Cc4ccc(Cl)cc4)c(CC(C)(C)C(O)=O)c(S1)c23

InChI Key InChIKey=DQPPQABLZMJYBU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50045664   

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50045664(3-[1-(4-Chloro-benzyl)-6-(isoquinolin-3-ylmethoxy)...)
Affinity DataIC50: 390nMAssay Description:Tested for inhibition of leukotriene biosynthesis by binding to 5-lipoxygenase activating proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50045664(3-[1-(4-Chloro-benzyl)-6-(isoquinolin-3-ylmethoxy)...)
Affinity DataIC50: 20nMAssay Description:Tested for inhibition of 5-HPETE production by human 5-LOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50045664(3-[1-(4-Chloro-benzyl)-6-(isoquinolin-3-ylmethoxy)...)
Affinity DataIC50: 400nMAssay Description:In vitro test for inhibition of 5-lipoxygenase in cell-free preparations from rat PMN leukocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed