BDBM50048708 CHEMBL3318711

SMILES CC(Nc1ccccc1)c1cc(cn2c1nc(cc2=O)N1CCOCC1)C(=O)N(C)C

InChI Key InChIKey=NJQQDNUWDJNASH-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50048708   

LigandPNGBDBM50048708(CHEMBL3318711)
Affinity DataIC50: 560nMAssay Description:Inhibition of human recombinant PI3Kalpha assessed as depletion of ATP substrate by Ultra Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2016
Entry Details Article
PubMed
LigandPNGBDBM50048708(CHEMBL3318711)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant PI3Kbeta assessed as depletion of ATP substrate by Ultra Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2016
Entry Details Article
PubMed
LigandPNGBDBM50048708(CHEMBL3318711)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human recombinant PI3Kgamma assessed as depletion of ATP substrate by Ultra Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2016
Entry Details Article
PubMed
LigandPNGBDBM50048708(CHEMBL3318711)
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant PI3Kdelta assessed as depletion of ATP substrate by Ultra Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2016
Entry Details Article
PubMed
LigandPNGBDBM50048708(CHEMBL3318711)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of PI3Kalpha in human BT474 cells assessed as inhibition of Tyr308 Akt phosphorylation after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2016
Entry Details Article
PubMed
LigandPNGBDBM50048708(CHEMBL3318711)
Affinity DataIC50: 156nMAssay Description:Inhibition of PI3Kbeta in human MAD-MB-468 cells assessed as inhibition of Ser473 Akt phosphorylation by cellular potency assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2016
Entry Details Article
PubMed
LigandPNGBDBM50048708(CHEMBL3318711)
Affinity DataIC50: 68nMAssay Description:Inhibition of human recombinant PI3Kbeta assessed as PIP3 production by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2016
Entry Details Article
PubMed
LigandPNGBDBM50048708(CHEMBL3318711)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human recombinant PI3Kalpha assessed as PIP3 production by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2016
Entry Details Article
PubMed