BDBM50048772 (R)-5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoic acid::CHEMBL283820

SMILES OC(=O)CC[C@@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1

InChI Key InChIKey=FJCZHMXAGBYXHJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50048772   

TargetGastrin/cholecystokinin type B receptor(Human)
Rotta Research Laboratorium

Curated by ChEMBL
LigandPNGBDBM50048772((R)-5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-b...)
Affinity DataIC50: 1.22E+3nMAssay Description:In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50048772((R)-5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-b...)
Affinity DataIC50: 1.35E+4nMAssay Description:Displacement of [125I](BH)-CCK-8 to Cholecystokinin type A receptor in rat pancreatic aciniMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetGastrin/cholecystokinin type B receptor(Human)
Rotta Research Laboratorium

Curated by ChEMBL
LigandPNGBDBM50048772((R)-5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-b...)
Affinity DataIC50: 1.40E+3nMAssay Description:Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetCholecystokinin receptor type A(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50048772((R)-5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-b...)
Affinity DataIC50: 1.35E+4nMAssay Description:Inhibition of [125I]CCK-8 binding to Cholecystokinin type A receptor in rat pancreasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Rotta Research Laboratorium

Curated by ChEMBL
LigandPNGBDBM50048772((R)-5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-b...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed