BDBM50051893 2-(5,5-Dimethyl-[1,3]dioxan-2-yl)-4,5-diphenyl-1H-imidazole::CHEMBL286812

SMILES CC1(C)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1

InChI Key InChIKey=GYFQLJRMPAKHQL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50051893   

TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50051893(2-(5,5-Dimethyl-[1,3]dioxan-2-yl)-4,5-diphenyl-1H-...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibitory concentration was evaluated as concentration required to inhibit 50% activity of the rabbit liver Acyl coenzyme A:cholesterol acyltransfer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50051893(2-(5,5-Dimethyl-[1,3]dioxan-2-yl)-4,5-diphenyl-1H-...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibitory concentration was evaluated as concentration required to inhibit 50% activity of the rabbit artery Acyl coenzyme A:cholesterol acyltransfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50051893(2-(5,5-Dimethyl-[1,3]dioxan-2-yl)-4,5-diphenyl-1H-...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibitory concentration was evaluated as concentration required to inhibit 50% activity of the rabbit liver Acyl coenzyme A:cholesterol acyltransfer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50051893(2-(5,5-Dimethyl-[1,3]dioxan-2-yl)-4,5-diphenyl-1H-...)
Affinity DataIC50: 75nMAssay Description:In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed