BDBM50051918 CHEMBL35222::N*6*-Methyl-N*6*-(2,3,4-trimethoxy-benzyl)-pyrido[2,3-d]pyrimidine-2,4,6-triamine

SMILES COc1ccc(CN(C)c2cnc3nc(N)nc(N)c3c2)c(OC)c1OC

InChI Key InChIKey=JEVMSWYIFZJASI-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50051918   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051918(N*6*-Methyl-N*6*-(2,3,4-trimethoxy-benzyl)-pyrido[...)
Affinity DataIC50: 26nMAssay Description:Inhibitory activity against Toxoplasma gondii dihydrofolate reductase (in 90 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051918(N*6*-Methyl-N*6*-(2,3,4-trimethoxy-benzyl)-pyrido[...)
Affinity DataIC50: 26nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051918(N*6*-Methyl-N*6*-(2,3,4-trimethoxy-benzyl)-pyrido[...)
Affinity DataIC50: 26nMAssay Description:Inhibitory activity against Toxoplasma gondii dihydrofolate reductase (in 50 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051918(N*6*-Methyl-N*6*-(2,3,4-trimethoxy-benzyl)-pyrido[...)
Affinity DataIC50: 30nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051918(N*6*-Methyl-N*6*-(2,3,4-trimethoxy-benzyl)-pyrido[...)
Affinity DataIC50: 30nMAssay Description:Inhibitory activity against rat liver dihydrofolate reductase (in 90 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051918(N*6*-Methyl-N*6*-(2,3,4-trimethoxy-benzyl)-pyrido[...)
Affinity DataIC50: 79nMAssay Description:Inhibitory activity against Pneumocystis carinii dihydrofolate reductase (in 90 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051918(N*6*-Methyl-N*6*-(2,3,4-trimethoxy-benzyl)-pyrido[...)
Affinity DataIC50: 79nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051918(N*6*-Methyl-N*6*-(2,3,4-trimethoxy-benzyl)-pyrido[...)
Affinity DataIC50: 530nMAssay Description:Inhibitory activity against recombinant human dihydrofolate reductase(in 50 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed