BDBM50053175 (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-((E)-2-thiazol-5-yl-vinyl)-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL333330

SMILES C[C@]1(\C=C\c2cncs2)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O

InChI Key InChIKey=MXGCFDVNRRWXED-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50053175   

TargetPenicillin-binding protein 2(Staphylococcus aureus)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50053175((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-((E)-2-thiazol-...)
Affinity DataIC50: 2.80E+4nMAssay Description:Compound was tested for inhibition of Penicillin-binding protein 2 from Staphylococcus aureus (Schoch).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetPenicillin-binding protein 2(Staphylococcus aureus)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50053175((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-((E)-2-thiazol-...)
Affinity DataIC50: 1.40E+4nMAssay Description:Compound was tested for inhibition of Penicillin-binding protein 2 from Escherichia coli.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetPenicillin-binding protein, transpeptidase domain protein(Staphylococcus aureus)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50053175((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-((E)-2-thiazol-...)
Affinity DataIC50: 3.00E+5nMAssay Description:Compound was tested for inhibition of Penicillin-binding protein 3 from Escherichia coli.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetPenicillin-binding protein 2(Staphylococcus aureus)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50053175((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-((E)-2-thiazol-...)
Affinity DataIC50: 8.00E+4nMAssay Description:Compound was tested for inhibition of 604 Cephalosporin resistant mutants of Penicillin-binding protein 2 from Streptococcus pneumoniaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetPenicillin-binding protein, transpeptidase domain protein(Staphylococcus aureus)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50053175((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-((E)-2-thiazol-...)
Affinity DataIC50: 2.80E+4nMAssay Description:Compound was tested for inhibition of Penicillin-binding protein 3 from Staphylococcus aureus (Schoch).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetPenicillin-binding protein 4(Staphylococcus aureus)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50053175((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-((E)-2-thiazol-...)
Affinity DataIC50: 1.43E+5nMAssay Description:Compound was tested for inhibition of Penicillin-binding protein 4 from Staphylococcus aureus (Schoch).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetPenicillin-binding protein 1B(Escherichia coli (strain K12))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50053175((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-((E)-2-thiazol-...)
Affinity DataIC50: 1.00E+7nMAssay Description:Compound was tested for inhibition of Penicillin-binding protein 1b from Escherichia coli.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetPenicillin-binding protein 2(Staphylococcus aureus)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50053175((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-((E)-2-thiazol-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Compound was tested for inhibition of 503 Cephalosporin resistant mutants of Penicillin-binding protein 2 from Streptococcus pneumoniaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetBeta-lactamase(Bacillus licheniformis)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50053175((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-((E)-2-thiazol-...)
Affinity DataIC50: 5.40E+3nMAssay Description:Compound was tested for inhibition of Bacillus licheniformis 749/C, class A of Beta-lactamaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetBeta-lactamase(Citrobacter freundii)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50053175((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-((E)-2-thiazol-...)
Affinity DataIC50: 1.30E+3nMAssay Description:Compound was tested for inhibition of Citrobacter freundii 1928, class C of Beta-lactamaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50053175((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-((E)-2-thiazol-...)
Affinity DataIC50: 4.50E+4nMAssay Description:Compound was tested for inhibition of Escherichia coli AmpC, class C of Beta-lactamaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetBeta-lactamase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50053175((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-((E)-2-thiazol-...)
Affinity DataIC50: 540nMAssay Description:Compound was tested for inhibition of Pseudomonas aeruginosa 18SH, class C of Beta-lactamaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed