BDBM50053464 1-Phenyl-[1,2,4]triazinan-3-one::1-phenyl-1,2,4-triazinan-3-one::CHEMBL340341

SMILES O=C1NCCN(N1)c1ccccc1

InChI Key InChIKey=PBAAMDZDOAGGRJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50053464   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50053464(1-Phenyl-[1,2,4]triazinan-3-one | 1-phenyl-1,2,4-t...)
Affinity DataIC50: 4.60E+3nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against calcium ionophore (A23187) induced LTB4 formation in rat polymorphonuclear leukocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50053464(1-Phenyl-[1,2,4]triazinan-3-one | 1-phenyl-1,2,4-t...)
Affinity DataIC50: 5.80E+3nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against calcium ionophore (A23187) induced LTB4 formation in human polymorphonuclear leukocytes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50053464(1-Phenyl-[1,2,4]triazinan-3-one | 1-phenyl-1,2,4-t...)
Affinity DataIC50: 5.80E+3nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against calcium ionophore (A23187) induced LTB4 formation in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50053464(1-Phenyl-[1,2,4]triazinan-3-one | 1-phenyl-1,2,4-t...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of 5-lipoxygenase catalysis in rat basophilic leukemia (RBL) cells by measuring 5-HETE product formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed