BDBM50053691 3-{4-[4-(6-Fluoro-benzo[b]thiophen-3-yl)-piperazin-1-yl]-butyl}-2-methyl-1-thia-3-aza-spiro[4.4]nonan-4-one::CHEMBL131482

SMILES CC1SC2(CCCC2)C(=O)N1CCCCN1CCN(CC1)c1csc2cc(F)ccc12

InChI Key InChIKey=SYTKLFTVOOOLQR-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50053691   

TargetD(4) dopamine receptor(Human)
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50053691(3-{4-[4-(6-Fluoro-benzo[b]thiophen-3-yl)-piperazin...)
Affinity DataIC50: 713nMAssay Description:Inhibitory concentration against human Dopamine receptor D4.2 in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50053691(3-{4-[4-(6-Fluoro-benzo[b]thiophen-3-yl)-piperazin...)
Affinity DataIC50: 954nMAssay Description:Binding affinity towards Dopamine receptor D2 was determined in rat striatum using [3H]- spiperone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50053691(3-{4-[4-(6-Fluoro-benzo[b]thiophen-3-yl)-piperazin...)
Affinity DataIC50: 189nMAssay Description:Binding affinity towards serotonin 5-HT1A receptor was determined in rat hippocampus using [3H]8-OH-DPAT as ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50053691(3-{4-[4-(6-Fluoro-benzo[b]thiophen-3-yl)-piperazin...)
Affinity DataIC50: 8nMAssay Description:Inhibitory concentration against human 5-HT2A receptor in BEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50053691(3-{4-[4-(6-Fluoro-benzo[b]thiophen-3-yl)-piperazin...)
Affinity DataKi:  4nMAssay Description:Binding affinity towards human 5-HT2A receptor in BEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50053691(3-{4-[4-(6-Fluoro-benzo[b]thiophen-3-yl)-piperazin...)
Affinity DataKi:  117nMAssay Description:Binding affinity against human Dopamine receptor D4.2 in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed