BDBM50054742 1,4-Bis-(2-benzhydryloxy-ethyl)-piperazine::CHEMBL143612

SMILES C(CN1CCN(CCOC(c2ccccc2)c2ccccc2)CC1)OC(c1ccccc1)c1ccccc1

InChI Key InChIKey=OYZBDSAALZWYTR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50054742   

TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50054742(1,4-Bis-(2-benzhydryloxy-ethyl)-piperazine | CHEMB...)
Affinity DataIC50: 1.60nMAssay Description:Compound was tested for binding against Dopamine transporter using radioligand as [3H]-RTI 55More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50054742(1,4-Bis-(2-benzhydryloxy-ethyl)-piperazine | CHEMB...)
Affinity DataIC50: 9.30nMAssay Description:Binding against Dopamine transporter using radioligand as [3H]GBR 12935More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50054742(1,4-Bis-(2-benzhydryloxy-ethyl)-piperazine | CHEMB...)
Affinity DataIC50: 12nMAssay Description:Inhibition of dopamine DA reuptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50054742(1,4-Bis-(2-benzhydryloxy-ethyl)-piperazine | CHEMB...)
Affinity DataIC50: 1.71E+3nMAssay Description:Inhibition of [3H]5-HT reuptake at rat serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50054742(1,4-Bis-(2-benzhydryloxy-ethyl)-piperazine | CHEMB...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity against sigma receptor using radioligand ([3H](+)-pentazocine) binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed