BDBM50055910 CHEMBL3321923::US9884814, Compound 13

SMILES COc1ccc(CC(=O)NC(=N)N[C@H](Cc2ccccc2)C(=O)NCCN2C(=O)c3ccccc3C2=O)cc1OC

InChI Key InChIKey=ZVHZJFRBDYJHEP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50055910   

TargetRenin(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50055910(CHEMBL3321923 | US9884814, Compound 13)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of human recombinant renin using quenched Dabcyl-g-Abu-IHPFHLVIHT-Edans peptide substrate by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetCathepsin D(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50055910(CHEMBL3321923 | US9884814, Compound 13)
Affinity DataIC50: 320nMAssay Description:Inhibition of human liver cathepsin D using MCA-labeled GKPILFFRLK(Dnp)-D-R-NH2 peptide by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetCathepsin D(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50055910(CHEMBL3321923 | US9884814, Compound 13)
Affinity DataIC50: 180nMpH: 5.5 T: 2°CAssay Description:In order to identify modulators of cathepsin D activity, a continuous enzymatic test was carried out with a synthetic peptide which carries a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent