BDBM50056199 CHEMBL3329684

SMILES COc1ccc(C(=O)NC(=O)Nc2ccc3\C(=C\c4[nH]c(C)c(C(=O)NCCN5CCCC5)c4C)C(=O)Nc3c2)c(F)c1

InChI Key InChIKey=NKKNQMFHKZEGQU-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50056199   

TargetAurora kinase A(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of Aurora-A (unknown origin) by kinase-glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAurora kinase B(Human)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of Aurora B (unknown origin) using HLRRASLG substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of FLT3 (unknown origin) using EAIYAAPFAKKK substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of Lck (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50: 14nMAssay Description:Inhibition of c-Kit (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50: 9.67E+3nMAssay Description:Inhibition of human ERG channel after 3 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using Vivid OOMR substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin) using 3-cyano-7-ethoxycoumarin substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin) using 3-cyano-7-ethoxycoumarin substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin) using Vivid OOMR substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCytochrome P450 1A1(Human)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin) using 3-cyano-7-ethoxycoumarin substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed