BDBM50056557 1-(2-Benzhydryloxy-ethyl)-4-((E)-3-furan-2-yl-allyl)-piperazine::CHEMBL346591

SMILES C(CN1CCN(C\C=C\c2ccco2)CC1)OC(c1ccccc1)c1ccccc1

InChI Key InChIKey=RISQRACQCSRCMX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50056557   

TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50056557(1-(2-Benzhydryloxy-ethyl)-4-((E)-3-furan-2-yl-ally...)
Affinity DataIC50: 5nMAssay Description:Binding affinity at the dopamine transporter using [125I]RTI-55 in rat caudate membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50056557(1-(2-Benzhydryloxy-ethyl)-4-((E)-3-furan-2-yl-ally...)
Affinity DataIC50: 9.60nMAssay Description:Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]dopamine on synaptosomes obtained from rat caudate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50056557(1-(2-Benzhydryloxy-ethyl)-4-((E)-3-furan-2-yl-ally...)
Affinity DataIC50: 1.84E+3nMAssay Description:Binding affinity at the serotonin transporter using [125I]RTI-55 in rat caudate membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50056557(1-(2-Benzhydryloxy-ethyl)-4-((E)-3-furan-2-yl-ally...)
Affinity DataIC50: 2.70E+3nMAssay Description:Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]-5-HT on synaptosomes obtained from whole rat brain minus cerebellum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed