BDBM50056573 1-(2-Benzhydryloxy-ethyl)-4-((E)-3-thiophen-2-yl-allyl)-piperazine::CHEMBL159489

SMILES C(CN1CCN(C\C=C\c2cccs2)CC1)OC(c1ccccc1)c1ccccc1

InChI Key InChIKey=VHARAMYFMYXHSB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50056573   

TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50056573(1-(2-Benzhydryloxy-ethyl)-4-((E)-3-thiophen-2-yl-a...)
Affinity DataIC50: 6.40nMAssay Description:Binding affinity at the dopamine transporter using [125I]RTI-55 in rat caudate membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50056573(1-(2-Benzhydryloxy-ethyl)-4-((E)-3-thiophen-2-yl-a...)
Affinity DataIC50: 10nMAssay Description:Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]dopamine on synaptosomes obtained from rat caudate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50056573(1-(2-Benzhydryloxy-ethyl)-4-((E)-3-thiophen-2-yl-a...)
Affinity DataIC50: 1.17E+3nMAssay Description:Binding affinity at the serotonin transporter using [125I]RTI-55 in rat caudate membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50056573(1-(2-Benzhydryloxy-ethyl)-4-((E)-3-thiophen-2-yl-a...)
Affinity DataIC50: 2.02E+3nMAssay Description:Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]-5-HT on synaptosomes obtained from whole rat brain minus cerebellum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed