BDBM50056575 1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-4-(3-pyridin-3-yl-propyl)-piperazine::CHEMBL159608

SMILES Fc1ccc(cc1)C(OCCN1CCN(CCCc2cccnc2)CC1)c1ccc(F)cc1

InChI Key InChIKey=YSPRAXVSVOUKSE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50056575   

TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50056575(1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-4-(3-p...)
Affinity DataIC50: 16nMAssay Description:Binding affinity was determined at the dopamine transporter labeled with radioligand [125 I] RTI-55More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50056575(1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-4-(3-p...)
Affinity DataIC50: 20nMAssay Description:Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]dopamine on synaptosomes obtained from rat caudate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50056575(1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-4-(3-p...)
Affinity DataIC50: 79nMAssay Description:Sigma receptor binding was determined by labeling with radioligand [3H](+)-pentazocine on frozen membranes obtained from frozen guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50056575(1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-4-(3-p...)
Affinity DataIC50: 2.80E+3nMAssay Description:Binding affinity was determined at the Serotonin transporter labeled with radioligand [125 I] RTI-55More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50056575(1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-4-(3-p...)
Affinity DataIC50: 6.52E+3nMAssay Description:Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]-5-HT on synaptosomes obtained from whole rat brain minus cerebellum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed