BDBM50057297 (5aS,7aS,8S,10aS,10bS)-8-Hydroxy-7a-methyl-3,4,6,7,7a,8,9,10,10a,10b,11,12-dodecahydro-5aH-indeno[4,5-c]quinolizin-2-one::CHEMBL269632

SMILES C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CCN34)[C@@H]1CC[C@@H]2O

InChI Key InChIKey=UTDXFFWXJOMGPG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50057297   

Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM50057297((5aS,7aS,8S,10aS,10bS)-8-Hydroxy-7a-methyl-3,4,6,7...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition against 5 alpha R-2 in human prostate homogenate relative to finasterideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM50057297((5aS,7aS,8S,10aS,10bS)-8-Hydroxy-7a-methyl-3,4,6,7...)
Affinity DataIC50: 409nMAssay Description:Inhibitory activity against human 5-alpha Reductase-1 expressed in DU-145 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM50057297((5aS,7aS,8S,10aS,10bS)-8-Hydroxy-7a-methyl-3,4,6,7...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibitory activity against 5-alpha Reductase-2 on human prostate homogenates from surgically derived benign hyperplastic tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed