BDBM50061484 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid pyridin-3-ylamide::CHEMBL130362

SMILES Clc1ccc2C(N3CCN(CC3)C(=O)Nc3cccnc3)c3ncccc3CCc2c1

InChI Key InChIKey=UYAWMLCIDQNGSJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50061484   

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50061484(4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibitory activity against recombinant human farnesyltransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50061484(4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1...)
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of rat Geranylgeranyl transferase (GGPT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50061484(4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1...)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of Farnesyltransferase from Ras-CVLS or Ras-CVLL in Cos-7 monkey kidney cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50061484(4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1...)
Affinity DataIC50: 1.34E+3nMAssay Description:In vitro inhibition of farnesyltransferase farnesylation of the H-ras oncogeneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed