BDBM50061603 CHEMBL3394167::US9321756, 157

SMILES CC(C)Oc1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1

InChI Key InChIKey=FLPSOVPOQWHOJV-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50061603   

TargetSerine/threonine-protein kinase pim-3(Human)
Amgen

US Patent
LigandPNGBDBM50061603(CHEMBL3394167 | US9321756, 157)
Affinity DataIC50: 1.58nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Amgen

US Patent
LigandPNGBDBM50061603(CHEMBL3394167 | US9321756, 157)
Affinity DataIC50: 7.77nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Amgen

US Patent
LigandPNGBDBM50061603(CHEMBL3394167 | US9321756, 157)
Affinity DataIC50: 10.1nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Amgen

US Patent
LigandPNGBDBM50061603(CHEMBL3394167 | US9321756, 157)
Affinity DataIC50: 106nMAssay Description:Inhibition of PIM1 in human U2OS cells assessed as phosphorylation of BADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Amgen

US Patent
LigandPNGBDBM50061603(CHEMBL3394167 | US9321756, 157)
Affinity DataIC50: 7nMAssay Description:Inhibition of full length recombinant PIM1 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Amgen

US Patent
LigandPNGBDBM50061603(CHEMBL3394167 | US9321756, 157)
Affinity DataIC50: 10nMAssay Description:Inhibition of full length recombinant PIM2 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-3(Human)
Amgen

US Patent
LigandPNGBDBM50061603(CHEMBL3394167 | US9321756, 157)
Affinity DataIC50: 2nMAssay Description:Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Amgen

US Patent
LigandPNGBDBM50061603(CHEMBL3394167 | US9321756, 157)
Affinity DataIC50: 2.22E+3nMAssay Description:Inhibition of PIM2 in human U2OS cells assessed as phosphorylation of BADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed