BDBM50061612 CHEMBL3394168::US9321756, 163

SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(OC4CCCC4)n3)c2c1

InChI Key InChIKey=PNAYFCPGKVJMMN-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50061612   

TargetSerine/threonine-protein kinase pim-3(Human)
Amgen

US Patent
LigandPNGBDBM50061612(CHEMBL3394168 | US9321756, 163)
Affinity DataIC50: 4.58nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Amgen

US Patent
LigandPNGBDBM50061612(CHEMBL3394168 | US9321756, 163)
Affinity DataIC50: 14.7nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Amgen

US Patent
LigandPNGBDBM50061612(CHEMBL3394168 | US9321756, 163)
Affinity DataIC50: 40.8nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Amgen

US Patent
LigandPNGBDBM50061612(CHEMBL3394168 | US9321756, 163)
Affinity DataIC50: 479nMAssay Description:Inhibition of PIM1 in human U2OS cells assessed as phosphorylation of BADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Amgen

US Patent
LigandPNGBDBM50061612(CHEMBL3394168 | US9321756, 163)
Affinity DataIC50: 15nMAssay Description:Inhibition of full length recombinant PIM1 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Amgen

US Patent
LigandPNGBDBM50061612(CHEMBL3394168 | US9321756, 163)
Affinity DataIC50: 41nMAssay Description:Inhibition of full length recombinant PIM2 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-3(Human)
Amgen

US Patent
LigandPNGBDBM50061612(CHEMBL3394168 | US9321756, 163)
Affinity DataIC50: 5nMAssay Description:Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Amgen

US Patent
LigandPNGBDBM50061612(CHEMBL3394168 | US9321756, 163)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of PIM2 in human U2OS cells assessed as phosphorylation of BADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed