BDBM50061627 CHEMBL3394066::US9321756, 14

SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(n3)N3CCCC3)c2c1

InChI Key InChIKey=WHKBERSELXLKHK-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50061627   

TargetSerine/threonine-protein kinase pim-3(Human)
Amgen

US Patent
LigandPNGBDBM50061627(CHEMBL3394066 | US9321756, 14)
Affinity DataIC50: 14.5nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Amgen

US Patent
LigandPNGBDBM50061627(CHEMBL3394066 | US9321756, 14)
Affinity DataIC50: 11.1nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Amgen

US Patent
LigandPNGBDBM50061627(CHEMBL3394066 | US9321756, 14)
Affinity DataIC50: 43.5nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Amgen

US Patent
LigandPNGBDBM50061627(CHEMBL3394066 | US9321756, 14)
Affinity DataIC50: 42.0nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Amgen

US Patent
LigandPNGBDBM50061627(CHEMBL3394066 | US9321756, 14)
Affinity DataIC50: 104nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Amgen

US Patent
LigandPNGBDBM50061627(CHEMBL3394066 | US9321756, 14)
Affinity DataIC50: 8.91nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Amgen

US Patent
LigandPNGBDBM50061627(CHEMBL3394066 | US9321756, 14)
Affinity DataIC50: 48nMAssay Description:Inhibition of full length recombinant PIM1 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Amgen

US Patent
LigandPNGBDBM50061627(CHEMBL3394066 | US9321756, 14)
Affinity DataIC50: 104nMAssay Description:Inhibition of full length recombinant PIM2 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Amgen

US Patent
LigandPNGBDBM50061627(CHEMBL3394066 | US9321756, 14)
Affinity DataIC50: 3.16E+4nMAssay Description:Inhibition of PIM2 in human U2OS cells assessed as phosphorylation of BADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-3(Human)
Amgen

US Patent
LigandPNGBDBM50061627(CHEMBL3394066 | US9321756, 14)
Affinity DataIC50: 15nMAssay Description:Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Amgen

US Patent
LigandPNGBDBM50061627(CHEMBL3394066 | US9321756, 14)
Affinity DataIC50: 526nMAssay Description:Inhibition of PIM1 in human U2OS cells assessed as phosphorylation of BADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed