BDBM50061916 3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-benzenesulfonamide::CHEMBL134915

SMILES COc1ccc(cc1OC)S(=O)(=O)Nc1nc(cs1)-c1cccc(c1)[N+]([O-])=O

InChI Key InChIKey=NDPBMCKQJOZAQX-UHFFFAOYSA-N

Data  1 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50061916   

TargetKynurenine 3-monooxygenase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataIC50: 37nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Mouse)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataIC50: 90nMAssay Description:Inhibition of C57BL/6J mouse KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataIC50: 22nMAssay Description:Inhibition of Wistar rat KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Human)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataIC50: 170nMAssay Description:Inhibition of human KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Human)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS analysis i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Mouse)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of C57BL/6J mouse KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of Wistar rat KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Human)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataIC50: 37nMAssay Description:Inhibition of human KMOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Human)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataIC50: 37nMAssay Description:Inhibition of KMO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2019
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Human)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataIC50: 37nMAssay Description:Inhibition of KMO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetKynurenine 3-monooxygenase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataIC50: 37nMAssay Description:Inhibition of rat kidney KMOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetKynurenine 3-monooxygenase(Human)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataIC50: 37nMAssay Description:Inhibition of KMO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetKynurenine 3-monooxygenase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataKi:  4.80nMAssay Description:Inhibitory constant against Kynurenine 3-hydroxylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed