BDBM50064101 CHEMBL290304::{[(S)-1-[3-(2-Amino-ethyl)-1H-indol-2-ylcarbamoyl]-4-(2-fluoro-phenyl)-but-3-ynylamino]-methyl}-phosphonic acid

SMILES NCCc1c(NC(=O)[C@H](CC#Cc2ccccc2F)NCP(O)(O)=O)[nH]c2ccccc12

InChI Key InChIKey=CZAWQIOULAMVAY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50064101   

TargetEndothelin-converting enzyme 1(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064101({[(S)-1-[3-(2-Amino-ethyl)-1H-indol-2-ylcarbamoyl]...)
Affinity DataIC50: 76nMAssay Description:Inhibitory activity was assessed on CHO cells expressing recombinant human Endothelin-converting enzyme 1 (ECE-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064101({[(S)-1-[3-(2-Amino-ethyl)-1H-indol-2-ylcarbamoyl]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed