BDBM50064105 CHEMBL446393::{(S)-3-[(S)-5-(2,4-Difluoro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetic acid

SMILES OC(=O)CN1c2ccccc2CC[C@H](NC(=O)[C@H](CC#Cc2ccc(F)cc2F)NCP(O)(O)=O)C1=O

InChI Key InChIKey=BNWWCJCEOOIWCA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50064105   

TargetEndothelin-converting enzyme 1(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064105({(S)-3-[(S)-5-(2,4-Difluoro-phenyl)-2-(phosphonome...)
Affinity DataIC50: 82nMAssay Description:Inhibitory activity was assessed on CHO cells expressing recombinant human Endothelin-converting enzyme 1 (ECE-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064105({(S)-3-[(S)-5-(2,4-Difluoro-phenyl)-2-(phosphonome...)
Affinity DataIC50: 730nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed