BDBM50064111 CHEMBL35995::{[(S)-1-[3-(2-Amino-ethyl)-1H-indol-2-ylcarbamoyl]-4-(2,4-difluoro-phenyl)-but-3-ynylamino]-methyl}-phosphonic acid

SMILES NCCc1c(NC(=O)[C@H](CC#Cc2ccc(F)cc2F)NCP(O)(O)=O)[nH]c2ccccc12

InChI Key InChIKey=GHDFGPQHLSHHMQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50064111   

TargetEndothelin-converting enzyme 1(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064111({[(S)-1-[3-(2-Amino-ethyl)-1H-indol-2-ylcarbamoyl]...)
Affinity DataIC50: 111nMAssay Description:Inhibitory activity was assessed on CHO cells expressing recombinant human Endothelin-converting enzyme 1 (ECE-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064111({[(S)-1-[3-(2-Amino-ethyl)-1H-indol-2-ylcarbamoyl]...)
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed