BDBM50064113 CHEMBL40168::{[(S)-1-(2-Biphenyl-4-yl-ethylcarbamoyl)-4-(2,4-difluoro-phenyl)-but-3-ynylamino]-methyl}-phosphonic acid

SMILES OP(O)(=O)CN[C@@H](CC#Cc1ccc(F)cc1F)C(=O)NCCc1ccc(cc1)-c1ccccc1

InChI Key InChIKey=JWOKQGCIQICHIX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50064113   

TargetEndothelin-converting enzyme 1(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064113({[(S)-1-(2-Biphenyl-4-yl-ethylcarbamoyl)-4-(2,4-di...)
Affinity DataIC50: 28nMAssay Description:Inhibitory activity was assessed on CHO cells expressing recombinant human Endothelin-converting enzyme 1 (ECE-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064113({[(S)-1-(2-Biphenyl-4-yl-ethylcarbamoyl)-4-(2,4-di...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed