BDBM50065297 3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-one::3-[1-(4-Isopropyl-phenyl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one::CHEMBL48760

SMILES CC(C)c1ccc(\C=C2\C(=O)Nc3ccccc23)cc1

InChI Key InChIKey=IRQQWCZKCUQNSO-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50065297   

LigandPNGBDBM50065297(3-[1-(4-Isopropyl-phenyl)-meth-(E)-ylidene]-1,3-di...)
Affinity DataIC50: 5.25E+3nMAssay Description:Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sugen

Curated by ChEMBL
LigandPNGBDBM50065297(3-[1-(4-Isopropyl-phenyl)-meth-(E)-ylidene]-1,3-di...)
Affinity DataIC50: 1.00E+4nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50065297(3-[1-(4-Isopropyl-phenyl)-meth-(E)-ylidene]-1,3-di...)
Affinity DataIC50: 5.20E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50065297(3-[1-(4-Isopropyl-phenyl)-meth-(E)-ylidene]-1,3-di...)
Affinity DataIC50: 2.42E+4nMAssay Description:Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sugen

Curated by ChEMBL
LigandPNGBDBM50065297(3-[1-(4-Isopropyl-phenyl)-meth-(E)-ylidene]-1,3-di...)
Affinity DataIC50: 1.85E+4nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50065297(3-[1-(4-Isopropyl-phenyl)-meth-(E)-ylidene]-1,3-di...)
Affinity DataIC50: 1.69E+4nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymotrypsin-C(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50065297(3-[1-(4-Isopropyl-phenyl)-meth-(E)-ylidene]-1,3-di...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibitory activity against chymotrypsinogenMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50065297(3-[1-(4-Isopropyl-phenyl)-meth-(E)-ylidene]-1,3-di...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibitory activity against beta-lactamase in the presence of 500 mMKPi concentration of bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50065297(3-[1-(4-Isopropyl-phenyl)-meth-(E)-ylidene]-1,3-di...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibitory activity against cloned Dihydrofolate reductase (cDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50065297(3-[1-(4-Isopropyl-phenyl)-meth-(E)-ylidene]-1,3-di...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory activity against beta-lactamase in the presence of 5 mM KPi concentration of bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetBeta-galactosidase(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50065297(3-[1-(4-Isopropyl-phenyl)-meth-(E)-ylidene]-1,3-di...)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of Beta-galactosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50065297(3-[1-(4-Isopropyl-phenyl)-meth-(E)-ylidene]-1,3-di...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibitory activity against beta-lactamaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50065297(3-[1-(4-Isopropyl-phenyl)-meth-(E)-ylidene]-1,3-di...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibitory activity against beta-lactamase in the presence of 50 mM KPi concentration of bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50065297(3-[1-(4-Isopropyl-phenyl)-meth-(E)-ylidene]-1,3-di...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibitory activity against Amp C beta-LactamaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed