BDBM50066488 CHEMBL114833::N*6*-(2,4,5-Trimethoxy-benzyl)-quinazoline-2,4,6-triamine

SMILES COc1cc(OC)c(OC)cc1CNc1ccc2nc(N)nc(N)c2c1

InChI Key InChIKey=VPSFLLCJENAQMF-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50066488   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066488(N*6*-(2,4,5-Trimethoxy-benzyl)-quinazoline-2,4,6-t...)
Affinity DataIC50: 124nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066488(N*6*-(2,4,5-Trimethoxy-benzyl)-quinazoline-2,4,6-t...)
Affinity DataIC50: 140nMAssay Description:Inhibitory activity against recombinant Dihydrofolate reductase from Escherichia coli (ecDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066488(N*6*-(2,4,5-Trimethoxy-benzyl)-quinazoline-2,4,6-t...)
Affinity DataIC50: 540nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066488(N*6*-(2,4,5-Trimethoxy-benzyl)-quinazoline-2,4,6-t...)
Affinity DataIC50: 540nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066488(N*6*-(2,4,5-Trimethoxy-benzyl)-quinazoline-2,4,6-t...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibitory activity against Dihydrofolate reductase from recombinant human (hDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066488(N*6*-(2,4,5-Trimethoxy-benzyl)-quinazoline-2,4,6-t...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibitory activity against Dihydrofolate reductase from rat liver (rlDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066488(N*6*-(2,4,5-Trimethoxy-benzyl)-quinazoline-2,4,6-t...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Lactobacillus casei (lcDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066488(N*6*-(2,4,5-Trimethoxy-benzyl)-quinazoline-2,4,6-t...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066488(N*6*-(2,4,5-Trimethoxy-benzyl)-quinazoline-2,4,6-t...)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii (pcDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066488(N*6*-(2,4,5-Trimethoxy-benzyl)-quinazoline-2,4,6-t...)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed