BDBM50066489 CHEMBL114839::N*6*-(5,6,7,8-Tetrahydro-naphthalen-1-ylmethyl)-quinazoline-2,4,6-triamine

SMILES Nc1nc(N)c2cc(NCc3cccc4CCCCc34)ccc2n1

InChI Key InChIKey=NRQMIDHBGFQNEV-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50066489   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066489(N*6*-(5,6,7,8-Tetrahydro-naphthalen-1-ylmethyl)-qu...)
Affinity DataIC50: 90nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066489(N*6*-(5,6,7,8-Tetrahydro-naphthalen-1-ylmethyl)-qu...)
Affinity DataIC50: 99nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066489(N*6*-(5,6,7,8-Tetrahydro-naphthalen-1-ylmethyl)-qu...)
Affinity DataIC50: 150nMAssay Description:Inhibitory activity against recombinant Dihydrofolate reductase from Escherichia coli (ecDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066489(N*6*-(5,6,7,8-Tetrahydro-naphthalen-1-ylmethyl)-qu...)
Affinity DataIC50: 190nMAssay Description:Inhibitory activity against Dihydrofolate reductase from rat liver (rlDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066489(N*6*-(5,6,7,8-Tetrahydro-naphthalen-1-ylmethyl)-qu...)
Affinity DataIC50: 600nMAssay Description:Inhibitory activity against Dihydrofolate reductase from recombinant human (hDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066489(N*6*-(5,6,7,8-Tetrahydro-naphthalen-1-ylmethyl)-qu...)
Affinity DataIC50: 720nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii (pcDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066489(N*6*-(5,6,7,8-Tetrahydro-naphthalen-1-ylmethyl)-qu...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Lactobacillus casei (lcDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed