BDBM50066497 CHEMBL114354::N*6*-Methyl-N*6*-(5,6,7,8-tetrahydro-naphthalen-1-ylmethyl)-quinazoline-2,4,6-triamine

SMILES CN(Cc1cccc2CCCCc12)c1ccc2nc(N)nc(N)c2c1

InChI Key InChIKey=TUCQRMDCRDMAEG-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50066497   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066497(N*6*-Methyl-N*6*-(5,6,7,8-tetrahydro-naphthalen-1-...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066497(N*6*-Methyl-N*6*-(5,6,7,8-tetrahydro-naphthalen-1-...)
Affinity DataIC50: 5.40nMAssay Description:Inhibitory activity against recombinant Dihydrofolate reductase from Escherichia coli (ecDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066497(N*6*-Methyl-N*6*-(5,6,7,8-tetrahydro-naphthalen-1-...)
Affinity DataIC50: 17nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii (pcDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066497(N*6*-Methyl-N*6*-(5,6,7,8-tetrahydro-naphthalen-1-...)
Affinity DataIC50: 17nMAssay Description:Inhibitory activity against Dihydrofolate reductase from rat liver (rlDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066497(N*6*-Methyl-N*6*-(5,6,7,8-tetrahydro-naphthalen-1-...)
Affinity DataIC50: 21nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066497(N*6*-Methyl-N*6*-(5,6,7,8-tetrahydro-naphthalen-1-...)
Affinity DataIC50: 21nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Lactobacillus casei (lcDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066497(N*6*-Methyl-N*6*-(5,6,7,8-tetrahydro-naphthalen-1-...)
Affinity DataIC50: 21nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Lactobacillus casei (lcDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed