BDBM50066657 1,3-Bis-(4-methoxy-benzenesulfonyl)-hexahydro-pyrimidine-2-carboxylic acid hydroxyamide::CHEMBL333729

SMILES COc1ccc(cc1)S(=O)(=O)N1CCCN(C1C(=O)NO)S(=O)(=O)c1ccc(OC)cc1

InChI Key InChIKey=BCWUIVYEXBBRHO-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50066657   

TargetMatrix metalloproteinase-9(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50066657(1,3-Bis-(4-methoxy-benzenesulfonyl)-hexahydro-pyri...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of MMP9 (unknown origin) expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 20 to 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50066657(1,3-Bis-(4-methoxy-benzenesulfonyl)-hexahydro-pyri...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of Matrix metalloprotease-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50066657(1,3-Bis-(4-methoxy-benzenesulfonyl)-hexahydro-pyri...)
Affinity DataIC50: 33nMAssay Description:Inhibition of truncated human recombinant MMP3 catalytic domain expressed in Escherichia coli BL21(DE3) after 3 hrs in presence of [H]-transferrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetStromelysin-1(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50066657(1,3-Bis-(4-methoxy-benzenesulfonyl)-hexahydro-pyri...)
Affinity DataIC50: 33nMAssay Description:Inhibition of Matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066657(1,3-Bis-(4-methoxy-benzenesulfonyl)-hexahydro-pyri...)
Affinity DataIC50: 79nMAssay Description:Inhibition of Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066657(1,3-Bis-(4-methoxy-benzenesulfonyl)-hexahydro-pyri...)
Affinity DataIC50: 79nMAssay Description:Inhibition of human interstitial recombinant N-terminal MMP1 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetMatrilysin(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50066657(1,3-Bis-(4-methoxy-benzenesulfonyl)-hexahydro-pyri...)
Affinity DataIC50: 460nMAssay Description:Inhibition of MMP7 (unknown origin) expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 20 to 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetMatrilysin(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50066657(1,3-Bis-(4-methoxy-benzenesulfonyl)-hexahydro-pyri...)
Affinity DataIC50: 460nMAssay Description:Inhibition of Matrix metalloprotease-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed