BDBM50067860 CHEMBL141218::N*6*-(4-Methoxy-phenyl)-pyrido[3,2-d]pyrimidine-2,4,6-triamine

SMILES COc1ccc(Nc2ccc3nc(N)nc(N)c3n2)cc1

InChI Key InChIKey=QSLUSPPDJFCXMB-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50067860   

TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50067860(N*6*-(4-Methoxy-phenyl)-pyrido[3,2-d]pyrimidine-2,...)
Affinity DataIC50: 2.46E+3nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in consumption of NADPH using 9 uM DHFA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50067860(N*6*-(4-Methoxy-phenyl)-pyrido[3,2-d]pyrimidine-2,...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50067860(N*6*-(4-Methoxy-phenyl)-pyrido[3,2-d]pyrimidine-2,...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Toxoplasma gondiiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50067860(N*6*-(4-Methoxy-phenyl)-pyrido[3,2-d]pyrimidine-2,...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50067860(N*6*-(4-Methoxy-phenyl)-pyrido[3,2-d]pyrimidine-2,...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50067860(N*6*-(4-Methoxy-phenyl)-pyrido[3,2-d]pyrimidine-2,...)
Affinity DataIC50: 9.04E+4nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50067860(N*6*-(4-Methoxy-phenyl)-pyrido[3,2-d]pyrimidine-2,...)
Affinity DataIC50: 9.04E+4nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Pneumocystis cariniiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed