BDBM50068688 CHEMBL357823::[2'-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-4-isobutyl-biphenyl-2-ylamino]-acetic acid

SMILES CC(C)Cc1ccc(c(NCC(O)=O)c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C

InChI Key InChIKey=XYATVKNPIGPVIA-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50068688   

TargetEndothelin-1 receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068688([2'-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-4-isobut...)
Affinity DataKi:  89nMAssay Description:Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetEndothelin receptor type B(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068688([2'-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-4-isobut...)
Affinity DataKi:  1.20E+4nMAssay Description:Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed