BDBM50068752 8-Methyl-2-(4-nitro-phenyl)-3H-quinazolin-4-one::CHEMBL127396

SMILES Cc1cccc2c1nc([nH]c2=O)-c1ccc(cc1)[N+]([O-])=O

InChI Key InChIKey=NSQTWPGTGYHDIM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50068752   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50068752(8-Methyl-2-(4-nitro-phenyl)-3H-quinazolin-4-one | ...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human tankyrase2 after 2 hrs by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50068752(8-Methyl-2-(4-nitro-phenyl)-3H-quinazolin-4-one | ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant IMPDH2 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50068752(8-Methyl-2-(4-nitro-phenyl)-3H-quinazolin-4-one | ...)
Affinity DataIC50: 32nMAssay Description:Inhibition of human tankyrase1 after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Mouse)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068752(8-Methyl-2-(4-nitro-phenyl)-3H-quinazolin-4-one | ...)
Affinity DataIC50: 130nMAssay Description:Inhibition of the DNA repair Poly (ADP-ribose) polymerase 1, in permeabilised L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50068752(8-Methyl-2-(4-nitro-phenyl)-3H-quinazolin-4-one | ...)
Affinity DataIC50: 104nMAssay Description:Inhibition of PARP1 (unknown origin) after 1 hr by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed