BDBM50068778 CHEMBL3402398

SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc(cc3)C(C)(C)C)n2)c1

InChI Key InChIKey=CTOGRDMHAXLKPA-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50068778   

TargetTyrosine-protein kinase SYK(Human)
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM50068778(CHEMBL3402398)
Affinity DataEC50:  430nMAssay Description:Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM50068778(CHEMBL3402398)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of SYK in human mast cell cultures assessed as reduction in ionomycin-induced calcium mobilization mediated degranulation by tryptase rele...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2016
Entry Details Article
PubMed