BDBM50070061 CHEMBL3407821

SMILES Cc1cncn1-c1nccc(CCNCCCc2cccc(F)c2)n1

InChI Key InChIKey=XNNXUOKGLOGLRV-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50070061   

TargetCytochrome P450 3A4(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50070061(CHEMBL3407821)
Affinity DataIC50: 900nMAssay Description:Inhibition of human CYP3A4 using 7-benzyloxy-4-(trifluoromethyl)coumarin as substrate assessed as formation of 7-hydroxy-4-trifluoromethylcoumarin in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2016
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Rat)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50070061(CHEMBL3407821)
Affinity DataKi:  60nMAssay Description:Binding affinity to recombinant rat neuronal NOS overexpressed in Escherichia coli assessed as production of nitric oxide from L-arginine measured fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2016
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50070061(CHEMBL3407821)
Affinity DataKi:  303nMAssay Description:Binding affinity to recombinant human neuronal NOS overexpressed in Escherichia coli assessed as production of nitric oxide from L-arginine measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2016
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Bovine)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50070061(CHEMBL3407821)
Affinity DataKi:  1.54E+4nMAssay Description:Binding affinity to recombinant bovine endothelial NOS overexpressed in Escherichia coli assessed as production of nitric oxide from L-arginine measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2016
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50070061(CHEMBL3407821)
Affinity DataKi:  2.40E+4nMAssay Description:Binding affinity to recombinant mouse macrophage inducible NOS overexpressed in Escherichia coli assessed as production of nitric oxide from L-argini...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2016
Entry Details Article
PubMed