BDBM50070289 2-Benzyl-6-chloro-3-hydroxy-4-(propane-2-sulfonyl)-2H-isoquinolin-1-one::CHEMBL18020

SMILES CC(C)S(=O)(=O)c1c(O)n(Cc2ccccc2)c(=O)c2ccc(Cl)cc12

InChI Key InChIKey=AACXOSPRTYPFDW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50070289   

TargetProstaglandin G/H synthase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50070289(2-Benzyl-6-chloro-3-hydroxy-4-(propane-2-sulfonyl)...)
Affinity DataIC50: 60nMAssay Description:Concentration that caused a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 2 activity as measured by PGE-2 production.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50070289(2-Benzyl-6-chloro-3-hydroxy-4-(propane-2-sulfonyl)...)
Affinity DataIC50: 1.42E+3nMAssay Description:Concentration that caused a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 1 activity as measured by PGE-2 production.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed