BDBM50070530 1-[(1R,2R)-2-(2-Chloro-3-ethoxy-6-fluoro-phenyl)-cyclopropyl]-3-(5-cyano-pyridin-2-yl)-urea::CHEMBL38318

SMILES CCOc1ccc(F)c([C@H]2C[C@H]2NC(=O)Nc2ccc(cn2)C#N)c1Cl

InChI Key InChIKey=CBDHDNQKYMVBTK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50070530   

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM50070530(1-[(1R,2R)-2-(2-Chloro-3-ethoxy-6-fluoro-phenyl)-c...)
Affinity DataIC50: 4nMAssay Description:Inhibitory effect on wild type HIV- 1 reverse transcriptase using rCdG as template and dGTP as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM50070530(1-[(1R,2R)-2-(2-Chloro-3-ethoxy-6-fluoro-phenyl)-c...)
Affinity DataIC50: 70nMAssay Description:Inhibitory effect on recombinant HIV- 1 reverse transcriptase which has a mutation Tyr 181 to Cys 181 (clone 90)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM50070530(1-[(1R,2R)-2-(2-Chloro-3-ethoxy-6-fluoro-phenyl)-c...)
Affinity DataIC50: 80nMAssay Description:Inhibitory effect on recombinant HIV- 1 reverse transcriptase which has a mutation Leu 100 to Ile 100 (clone 118)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed